Paired TCRαβ analysis of virus‐specific CD8 + T cells exposes diversity in a previously defined ‘narrow’ repertoire
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چکیده
منابع مشابه
Maintenance of the EBV-specific CD8+ TCRαβ repertoire in immunosuppressed lung transplant recipients
Epstein-Barr virus (EBV) is one of the most common viruses in humans, capable of causing life-threatening infections and cancers in immunocompromised individuals. Although CD8+ T cells provide key protection against EBV, the persistence and dynamics of specific T-cell receptor (TCR) clones during immunosuppression in transplant patients is largely unknown. For the first time, we used a novel si...
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Wiskott-Aldrich syndrome (WAS) is an X-linked immunodeficiency characterized by thrombocytopenia, eczema, and variable degrees of impaired cellular and humoral immunity. Age-dependent T-cell lymphopenia has been described in WAS, however, the diversity of the T-cell compartment over time in these patients has not been characterized. We have used complementarity-determining region 3 (CDR3) size ...
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ژورنال
عنوان ژورنال: Immunology & Cell Biology
سال: 2015
ISSN: 0818-9641,1440-1711
DOI: 10.1038/icb.2015.44